I am using version 10912, and it doesn't seem to want to remember the last file I opened for analysis. Each time I open GenSmarts, it starts back in kiosk mode.
I have just unticked "kiosk mode" and now all seems well. Having also just read the help file, it clearly states that GenSmarts will ignore the last file opened option, if kiosk mode is set.
However, it would help greatly if this fact was identified on the File Handling Option tab.